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Increased complement-mediated leukocytic histamine release in atopics.

M Radermecker, M P Maldague, M Gustin

    International Archives of Allergy and Applied Immunology
    |January 1, 1982
    PubMed
    Summary
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    Atopic individuals exhibit significantly higher histamine release from leukocytes due to complement activation compared to normal subjects. This suggests an intrinsic basophil abnormality may underlie atopic conditions and related inflammatory diseases.

    Area of Science:

    • Immunology
    • Allergy Research

    Background:

    • Atopic individuals often exhibit heightened allergic responses.
    • The role of complement-mediated histamine release in atopy requires further elucidation.

    Purpose of the Study:

    • To compare complement-mediated histamine release from leukocytes in normal versus atopic subjects.
    • To investigate the underlying mechanisms of increased histamine release in atopy.

    Main Methods:

    • Isolated leukocytes and heparinized blood from normal and atopic subjects were incubated with zymosan-activated serum or particles.
    • Histamine release from basophils was quantified spectrofluorometrically.
    • Cross-experiments with isologous serum and passive sensitization with IgE antibodies were performed.

    Main Results:

    Related Experiment Videos

    • Atopic subjects showed significantly higher mean histamine release (47% leukocytes, 12% blood) than normal subjects (30% leukocytes, 5% blood).
    • Individual variations in histamine release were substantial but consistent between methods.
    • Complement activation intensity did not explain individual variability; IgE sensitization enhanced histamine release.

    Conclusions:

    • Higher complement-mediated histamine release is common in atopics, likely due to intrinsic basophil abnormalities.
    • Complement activation may play a critical role in house dust-induced asthma and other inhalant-related pulmonary diseases.
    • Exaggerated mediator releasability could predispose individuals to certain interstitial lung diseases.