[Possible relation between the immune response and thymus-dependence of the immunizing antigens in children in an...

As a result of serological examination of 7- to 14-year-old children in goiter endemic region it was shown that the activity of diphtheria and tetanus antitoxins is reduced in the initial stage of the thyroid enlargement, but prolonged antistrumin administration prevents this lowering. The relationship between these factors and immune response to polysaccharide antigens of typhoid vaccine was not observed. It is suggested that the dissimilar influence of the enlarged goiter initial forms and antithyroid prophylaxis on antibody genesis, induced by different antigens, is caused by an unequal role of the immune t-system.