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Updated: Aug 12, 2026
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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Adverse effects of granulocyte donations
Progress in Clinical and Biological Research
|January 1, 1982
Summary
Cytapheresis procedures can cause donor reactions, primarily vasovagal or citrate-related, which rarely halt the process. Component depletion can also limit donation frequency.
Area of Science:
- Hematology
- Transfusion Medicine
Background:
- Cytapheresis involves complex procedures with potential donor exposure to various agents.
- Reactions can occur due to the nature of intermittent or continuous flow centrifugation.
Purpose of the Study:
- To review and discuss adverse reactions and blood component depletion during cytapheresis.
- To understand the implications of these events on donor recruitment and procedure continuation.
Main Methods:
- Review of common and uncommon adverse reactions associated with cytapheresis.
- Discussion of blood component depletion in frequently repeated procedures.
Main Results:
- Most reactions are vasovagal (intermittent flow) or citrate-related (continuous flow) and rarely necessitate procedure cessation.
- Blood component depletion (red cells, platelets, plasma) can occur, potentially limiting donation frequency.
Conclusions:
- While most cytapheresis reactions are minor, they can impact procedural success and donor willingness.
- Managing reactions and component depletion is crucial for maintaining donor participation and recruitment.
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