Colloid bodies in dermatoses other than lichen planus

In a previous study on lichen planus the morphology and significance of the colloid bodies were discussed (13). In the present study a description is given of 30 dermatoses with colloid bodies, observed among unselected patients. The colloid bodies develop as a result of damage to the epithelium caused by circulatory disorders with subsequent hypo- or anoxia. Lichenoid cell infiltration into the connective tissue--nearly always present--aggravates the process. Dyskeratosis, pyknosis and fibrinoid necrosis of the damaged cells occur and the nuclei disintegrate. The resultant colloid bodies may coalesce or scatter or be expelled from the epithelium according to the principles of apoptosis (6, 7). Besides circulatory disorders, purely local damage and pathological processes involving the tissues should be regarded as important factors. Although the colloid bodies are characteristic for various skin diseases, they do not have an absolutely clear diagnostic significance. In doubtful cases their presence may nevertheless be considered a valuable contribution and supplement to the diagnosis.