Effects of interferon on sensitive and resistant L1210 cell lines

L1210 cells resistant to the antiviral and anticellular effects of interferon are not inducible for the 2,5A synthetase and for the protein kinase activities. Cloning of one resistant L1210 strain has revealed heterogeneity of the cell population with respect to their antiviral and anticellular response as well as protein kinase and 2,5A synthetase inducibility. The defect in the response of truly interferon-resistant L1210 cells appears to reside at an early step of interferon action.