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[Endogenous androgen levels of human prostatic tissues]
Nihon Naibunpi Gakkai Zasshi
|July 20, 1982
Summary
Benign prostatic hypertrophy (BPH) shows higher dihydrotestosterone (DHT) and lower 5 alpha-androstane 3 alpha, 17 beta diol (A-diol) levels than prostate cancer (PC). Measuring tissue DHT aids in assessing androgen dependency in prostate cancer.
Area of Science:
- Endocrinology
- Oncology
- Urology
Context:
- Androgens play a crucial role in the development and progression of prostate diseases.
- Radioimmunoassay with Sephadex LH-20 column chromatography enables precise measurement of endogenous androgens in small tissue samples.
Purpose:
- To quantify and compare endogenous androgen levels, specifically 5 alpha-androstane 3 alpha, 17 beta diol (A-diol) and dihydrotestosterone (DHT), in benign prostatic hypertrophy (BPH) and untreated prostate cancer (PC) tissues.
- To evaluate the relationship between tissue DHT levels and histological differentiation in prostate cancer.
Summary:
- Significant differences in androgen concentrations were observed between BPH and PC tissues.
- BPH tissues exhibited elevated DHT levels and reduced A-diol levels compared to PC tissues (P < 0.01).
- Prostate cancer tissues showed variable DHT levels, with a subset displaying levels below 2 ng/g, similar to non-androgen target tissues. Low DHT levels were noted even in well-differentiated prostate cancers.
Impact:
- The study highlights distinct androgen profiles in BPH and PC, suggesting differential androgen metabolism or regulation.
- Measurement of endogenous DHT levels in prostate tissue is a valuable tool for determining androgen dependency in prostate cancer, potentially guiding treatment strategies.