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[Immunoregulation by the gut-associated immune system].

W H Schmiegel, H G Thiele

    Immunitat Und Infektion
    |September 1, 1982
    PubMed
    Summary

    The gut immune system regulates local IgA responses and induces systemic immune tolerance to antigens. A newly identified contrasuppressor circuit in Peyer's plaques balances local immunity with systemic tolerance.

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    Area of Science:

    • Immunology
    • Gastroenterology
    • Microbiome research

    Context:

    • The gut-associated immune system (GAIS) is crucial for maintaining homeostasis.
    • It influences both local gut immunity and systemic immune responses.
    • Understanding GAIS mechanisms is key to addressing immune-related disorders.

    Purpose:

    • To elucidate the regulatory mechanisms of the gut-associated immune system.
    • To investigate the induction of antigen-specific systemic immune tolerance.
    • To explore the role of novel contrasuppressor circuits in immune regulation.

    Summary:

    • The GAIS manages local IgA responses and promotes antigen-specific systemic immune tolerance after oral antigen exposure.
    • Systemic tolerance is mediated by lymphatic cells and soluble factors like antibodies and immune complexes.
    • Emerging data indicate an antigen-specific lymphocytic contrasuppressor circuit within Peyer's plaques.

    Impact:

    • This contrasuppressor circuit interacts with helper and suppressor systems in Peyer's plaques.
    • It enables simultaneous local immune responses and systemic immune tolerance.
    • Findings offer new insights into immune regulation and potential therapeutic targets for autoimmune and allergic diseases.

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