Immunohistochemical demonstration of plasma proteins in experimentally produced eosinophilic bodies ("keratin pools")

Different opinions exist about the nature of the material in eosinophilic bodies, or "keratin pools", in the epithelium of the human oral mucosa. The material has been described as keratin-like and as a filtrate from the blood vessels. In the rat forestomach eosinophilic bodies develop in the hyperplastic squamous epithelium following administration of a chemical carcinogen. In the present study this model is used for immunohistochemical studies of eosinophilic bodies. They are shown to contain fibrinogen and immunoglobulin and thus seem to develop as a result of pooling of plasma exudate in the epithelium.