Experimental studies on the "cow's urine mixture"

Samples of the "Cow's Urine Mixture" (a traditional remedy for convulsions) administered intraperitoneally to fasting grey rabbits were found to produce significant depression of their plasma glucose. A similar effect on the plasma glucose was produced by a sample of Cow's Urine Mixture given by the nasogastric route. These findings confirm that the mixture has a significant hypoglycaemic effect when given both parenterally and enterally, the latter being the usual mode of administration of this concoction. The probable nature of the hypoglycaemic agents contained in the mixture is discussed.