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Related Experiment Videos

Histamine and the skin.

K J Misch, M W Greaves, A K Black

    The British Journal of Dermatology
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Histamine release is central to cold contact urticaria, but other factors like prostaglandin E also contribute to symptoms. Combined H1 and H2 receptor blockade may offer better treatment for this condition.

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    Area of Science:

    • Dermatology
    • Pharmacology
    • Immunology

    Background:

    • Urticaria is a common skin condition characterized by itchy welts.
    • Histamine is a key mediator in allergic reactions and urticaria.
    • Cold contact urticaria is a specific type of physical urticaria triggered by cold exposure.

    Purpose of the Study:

    • To review the role of histamine in urticaria, focusing on cold contact urticaria.
    • To explore the involvement of other pharmacological agents beyond histamine.
    • To discuss the implications of H1 and H2 receptors in blood vessels for urticaria treatment.

    Main Methods:

    • Review of experimental data on cold contact urticaria.
    • Analysis of the efficacy of drugs that suppress histamine release.

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  • Examination of evidence for prostaglandin E involvement.
  • Discussion of human blood vessel receptor pharmacology (H1 and H2).

    • Main Results:

    • Histamine release plays a central role in cold contact urticaria.
    • Drugs solely inhibiting histamine release do not fully alleviate symptoms, indicating other mediators.
    • Prostaglandin E is suggested as a potential contributing factor in some patients.
    • Human blood vessels have both H1 and H2 receptors, relevant for pharmacological blockade.

    Conclusions:

    • While histamine is crucial, other mediators like prostaglandin E are implicated in cold contact urticaria.
    • Combined H1 and H2 receptor blockade presents a potential therapeutic strategy for urticaria.
    • Further research into the multifaceted mechanisms of urticaria is warranted.