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Related Experiment Videos

AV pacing and LV performance.

R L Coskey, T S Feit, R Plaia

    Pacing and Clinical Electrophysiology : PACE
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    AV sequential pacing improved cardiac output in patients with impaired left ventricular function. Optimizing the AV interval non-invasively enhanced left ventricular performance, suggesting clinical utility.

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    Area of Science:

    • Cardiology
    • Biomedical Engineering

    Background:

    • Patients with impaired left ventricular function often have pacemakers.
    • AV sequential pacing aims to mimic natural cardiac conduction.

    Purpose of the Study:

    • To non-invasively evaluate left ventricular (LV) performance changes.
    • To assess the impact of pacing rate, mode, and AV interval on LV function.

    Main Methods:

    • Serial radionuclide angiograms were performed on five patients.
    • Patients had impaired LV function and AV sequential pacemakers.
    • Pacing parameters (rate, mode, AV interval) were manipulated.

    Main Results:

    • AV sequential pacing increased end-diastolic volume, end-systolic volume, stroke volume, and cardiac output compared to ventricular pacing.

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  • Ejection fraction and blood pressure showed no significant changes with varying AV sequential pacing rates.
  • A shorter AV interval (150 ms) improved LV performance more than a longer one (250 ms).

    • Conclusions:

    • Non-invasive optimization of LV performance is feasible using AV sequential pacemakers.
    • Varying heart rate, AV interval, and pacing mode can acutely improve LV function.
    • This technique may benefit select patients with cardiac conditions.