Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myelin basic protein and multiple sclerosis.

J N Whitaker

    Italian Journal of Neurological Sciences
    |June 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Myelin basic protein (BP) can trigger or prevent experimental allergic encephalomyelitis (EAE). Despite its presence in cerebrospinal fluid during multiple sclerosis (MS) flare-ups, BP has shown no therapeutic benefit for MS.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Benefit of interferon beta-1a on MSFC progression in secondary progressive MS.

    Neurology·2002
    Same author

    Metabolic differences between multiple sclerosis subtypes measured by quantitative MR spectroscopy.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2002
    Same author

    The confluence of quality of care, cost-effectiveness, pragmatism, and medical ethics in the diagnosis of nonepileptic seizures: a provocative situation for neurology.

    Archives of neurology·2001
    Same author

    Surgery for spinal cord compression in multiple sclerosis.

    Current opinion in neurology·2001
    Same author

    Medical and endovascular therapy for intracranial atherosclerotic vascular disease.

    Archives of neurology·2001
    Same author

    Triptans for migraine headache: therapeutic progress meets a heterogeneous patient response.

    Archives of neurology·2001
    Same journal

    Attualità in neurochirurgia : Edited by P. Paoletti, R. Kneich, R. Urcioli, C. Spairani Atti del XXXV Congresso Nazionale della Società Italiana di Neurochirurgia, September 1986. Mondadori Editore, 829 pages.

    Italian journal of neurological sciences·2016
    Same journal

    24th Annual Meeting of the Italian Neuropathological Association : May 26-27-28, 1988 Napoli, Castel dell'Ovo.

    Italian journal of neurological sciences·2016
    Same journal

    [Not Available].

    Italian journal of neurological sciences·2016
    Same journal

    [Not Available].

    Italian journal of neurological sciences·2016
    Same journal

    Pathogenesis and surgical treatment of neurovascular primary headaches.

    Italian journal of neurological sciences·2016
    Same journal

    The complementary contribution of the rhinologist and the neurologist at the clinical study and treatment of the cluster headache.

    Italian journal of neurological sciences·2016
    See all related articles

    Area of Science:

    • Neuroimmunology
    • Demyelinating Diseases

    Background:

    • Myelin basic protein (BP) plays a dual role in experimental allergic encephalomyelitis (EAE), capable of both inducing and suppressing the condition.
    • Immunoreactive BP and its fragments are detected in cerebrospinal fluid (CSF) during active phases of multiple sclerosis (MS) and acute central nervous system myelin damage.

    Purpose of the Study:

    • To investigate the role and potential therapeutic applications of myelin basic protein (BP) in the context of multiple sclerosis (MS).

    Main Methods:

    • Analysis of BP's capacity to induce and suppress EAE in animal models.
    • Detection of immunoreactive BP and fragments in CSF of patients with MS and acute CNS myelin damage.
    • Evaluation of humoral and cellular immune responses in CSF.
    • Assessment of therapeutic efficacy of BP in MS suppression attempts.

    Related Experiment Videos

    Main Results:

    • BP can induce and suppress EAE in animals.
    • BP or its fragments are found in CSF during active MS and acute CNS injury.
    • Immune responses in CSF related to BP have an uncertain role in MS etiology and pathogenesis.
    • Attempts to use BP for MS suppression yielded no therapeutic benefit.

    Conclusions:

    • Myelin basic protein (BP) has complex immunomodulatory effects relevant to demyelinating diseases like MS.
    • While BP is present during active MS, its direct therapeutic use for suppression has proven ineffective.