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Selection and evolution in macromolecular systems.

L Demetrius

    Journal of Theoretical Biology
    |August 21, 1983
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a discrete model for macromolecular evolution, using genealogies to analyze quasi-species dynamics. It defines entropy and adaptive value, linking them to environmental capacity and selective value.

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    Area of Science:

    • Evolutionary biology
    • Molecular evolution
    • Theoretical biology

    Background:

    • Quasi-species dynamics model macromolecular sequences evolving via mutation and replication.
    • Previous models used continuous dynamics to describe polynucleotide distributions under constant environments.

    Purpose of the Study:

    • To investigate quasi-species dynamics in both constant and variable environments using a discrete model.
    • To introduce and analyze notions of entropy, adaptive value, and environmental capacity based on genealogies.

    Main Methods:

    • Developed a discrete model for macromolecular evolution.
    • Introduced the concept of genealogy to track sequence evolution.
    • Defined entropy and adaptive value in terms of genealogies.

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    Main Results:

    • Established a framework to study quasi-species dynamics using discrete models and genealogies.
    • Introduced novel measures for quasi-species entropy, adaptive value, and environmental capacity.
    • Analyzed the relationship between these measures and the growth rate of quasi-species.

    Conclusions:

    • Genealogies provide a powerful tool for understanding quasi-species dynamics in discrete models.
    • The defined indices (entropy, adaptive value, environmental capacity) offer insights into selective value.
    • Conditions were identified where these indices align with the quasi-species growth rate.