Related Experiment Video
Updated: Jul 31, 2026

Programmed Electrical Stimulation in Mice
Published on: May 27, 2010
Increased risk of ventricular fibrillation associated with temporary pacemaker use during coronary arteriography
Insights
Temporary pacemakers during coronary arteriography significantly increase the risk of ventricular fibrillation, especially when combined with contrast dye injections. This finding highlights a critical safety consideration for patients undergoing cardiac procedures.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Imaging
Background:
- Coronary arteriography involves contrast dye injections that can transiently lower the ventricular fibrillation threshold.
- Factors promoting ventricular fibrillation during this procedure are not well-established.
Purpose of the Study:
- To investigate factors associated with dye-induced ventricular fibrillation during coronary arteriography.
Main Methods:
- Analysis of 3906 consecutive patients undergoing selective coronary arteriography with sodium meglumine diatrizoate.
- Comparison of ventricular fibrillation incidence between patients with and without temporary right ventricular pacemakers.
Main Results:
- Dye-induced ventricular fibrillation occurred in 1.7% of patients (66/3906).
- Patients with temporary right ventricular pacemakers had a nearly six-fold higher incidence of ventricular fibrillation (10% vs. 1.7%, P < .001).
- Patients receiving pacemakers had a higher prevalence of conduction abnormalities.
Conclusions:
- The use of temporary right ventricular pacemakers is a significant risk factor for ventricular fibrillation during coronary arteriography.
- Mechanical stimulation from pacing catheters may induce fibrillation more readily in contrast dye-sensitized ventricles.
Abstract:
Each injection of angiographic contrast dye during coronary arteriography represents a "natural experiment" in which the human ventricular fibrillation threshold is transiently reduced. Few factors, however, have been identified which favor the actual occurrence of ventricular fibrillation in this setting. Of 3906 consecutive patients undergoing selective coronary arteriography with sodium meglumine diatrizoate, 66 (1.7 percent) experienced dye-induced ventricular fibrillation, from which all were successfully defibrillated. Analysis of these cases revealed, unexpectedly, that patients in whom temporary right ventricular pacemakers were employed had an incidence of ventricular fibrillation nearly six times that found in the entire group undergoing arteriography (10 percent vs. 1.7 percent, respectively; P less than .001). Those individuals receiving pacemakers were distinguished from other studied patients only by a higher prevalence of conduction abnormalities. Although there is normally a low probability that mechanical stimulation by a pacing catheter can induce ventricular fibrillation, it is postulated that such an occurrence may be more likely after ventricular vulnerability has been increased by contrast dye.
Related Concept Videos
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Cardiac Catheterization I: Pre-Procedure Overview
Cardiac Catheterization II: Right Heart Catheterization
Cardiac Catheterization III: Left Heart Catheterization
Cardiac Catheterization IV: Nursing Management
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

