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Related Experiment Videos

Pancreatic hypersecretion in liver disease.

J A Gregg, M M Sharma

    The American Journal of Digestive Diseases
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Patients with liver cirrhosis may experience pancreatic hypersecretion, leading to large duodenal aspirates. This study clarifies the pancreas as a potential source of this fluid during secretin stimulation.

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    Area of Science:

    • Gastroenterology
    • Hepatology
    • Pancreatology

    Background:

    • Abnormal duodenal aspirates are common in liver cirrhosis patients.
    • The origin of this fluid (liver vs. pancreas) remains debated.

    Purpose of the Study:

    • To determine the source of large duodenal aspirates in cirrhosis patients.
    • To investigate pancreatic secretion during secretin stimulation in cirrhosis.

    Main Methods:

    • Endoscopic retrograde cholangiopancreatography (ERCP) with pancreatic duct cannulation.
    • Intraductal secretin test administered to assess pancreatic and bile flow.
    • Analysis of duodenal aspirates in 12 patients (11 cirrhosis, 1 cholestatic hepatitis).

    Main Results:

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  • Pancreatic hypersecretion (7.8–26.0 ml/min) observed in 6/11 cirrhosis patients.
  • Low pancreatic secretory flow rates in 3/11 cirrhosis patients.
  • Bile flow was negligible in most patients, indicating the pancreas as the primary source of fluid.

    • Conclusions:

    • Pancreatic hypersecretion is a significant finding in cirrhosis patients under secretin stimulation.
    • Potential causes include impaired secretin metabolism or early pancreatitis-associated hypersecretion.
    • This study identifies the pancreas as a key contributor to abnormal duodenal aspirates in cirrhosis.