Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amiodarone: individualizing dosage with serum concentrations.

H H Rotmensch, B N Swanson, A J Greenspon

    Pacing and Clinical Electrophysiology : PACE
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Potentially lethal interaction of cimetidine and morphine.

    Canadian Medical Association journal·2010
    Same author

    A novel miniature ventricular assist device for hemodynamic support.

    ASAIO journal (American Society for Artificial Internal Organs : 1992)·2001
    Same author

    Evolving indications for permanent pacemakers.

    Annals of internal medicine·2001
    Same author

    Avoiding complications of catheter ablation: a review of the current state of the art.

    The Journal of invasive cardiology·2001
    Same author

    The effectiveness of olanzapine in treatment-refractory schizophrenia when patients are nonresponsive to or unable to tolerate clozapine.

    Clinical therapeutics·2000
    Same author

    Insights into the mechanism of sustained ventricular tachycardia after myocardial infarction in a closed chest porcine model using a multielectrode "basket" catheter.

    Journal of cardiovascular electrophysiology·1999

    Maximizing amiodarone therapy involves a 400 mg maintenance dose, with serum concentrations below 2.5 mg/L improving the benefit-to-risk ratio. Consider adding other antiarrhythmics if initial treatment is ineffective.

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Cardiology

    Background:

    • Amiodarone is a potent antiarrhythmic drug.
    • Its efficacy and safety are closely linked to serum concentrations.
    • Optimizing amiodarone dosing is crucial for patient outcomes.

    Purpose of the Study:

    • To review pharmacokinetic data for amiodarone.
    • To present clinical experience in monitoring serum amiodarone levels.
    • To provide evidence-based recommendations for amiodarone dosing and management.

    Main Methods:

    • Review of existing pharmacokinetic literature on amiodarone.
    • Analysis of clinical data from patients undergoing amiodarone therapy.
    • Correlation of serum amiodarone concentrations with therapeutic outcomes and adverse events.

    Related Experiment Videos

    Main Results:

    • A maximal maintenance dose of 400 mg amiodarone is recommended.
    • Serum concentrations below 2.5 mg/L are associated with an improved benefit-to-risk ratio.
    • Adding other antiarrhythmic agents is preferred over increasing amiodarone dosage if treatment fails.

    Conclusions:

    • Therapeutic drug monitoring of serum amiodarone concentrations is essential.
    • Optimal amiodarone dosing strategies can enhance efficacy and minimize toxicity.
    • Individualized treatment adjustments are key for effective amiodarone management in arrhythmias.