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Hormonal-like modulation of growth of moloney virus-induced tumors by interferon and platelet-derived growth factor

A D Inglot, O Inglot

    Archivum Immunologiae Et Therapiae Experimentalis
    |January 1, 1983
    PubMed

    Insights

    High-dose mouse interferon (MuIFN) inhibited Moloney sarcoma virus (MSV) tumors, while low-dose MuIFN enhanced growth. Platelet-derived growth factor (PDGF) interacted with MuIFN, affecting tumor modulation in vivo.

    Area of Science:

    • Immunology
    • Oncology
    • Biochemistry

    Background:

    • Interferon (IFN) and platelet-derived growth factor (PDGF) are key biological molecules with known roles in cell growth and immune response.
    • Their interaction in the context of viral-induced tumors, specifically Moloney sarcoma virus (MSV) in mice, requires further elucidation.

    Purpose of the Study:

    • To investigate the dose-dependent effects of mouse interferon (MuIFN) on MSV-induced tumor growth.
    • To examine the combined effects of MuIFN and bovine platelet-derived growth factor (PDGF) on tumor modulation in vivo.
    • To explore the potential interaction between MuIFN and PDGF in modulating tumor development.

    Main Methods:

    • Balb/c mice infected with Moloney sarcoma virus (MSV) were treated with intramuscular (i.m.) injections of highly purified mouse interferon (MuIFN) and/or bovine platelet-derived growth factor (PDGF).
    • Different doses and schedules of MuIFN administration were employed: high-dose daily (10(5) units/mouse/day for 14 days) and low-dose daily (100 units/mouse/day for 14 days) or intermittently (10(4) units/mouse every second day).
    • Simultaneous administration of high-dose MuIFN and PDGF was also performed.

    Main Results:

    • High-dose MuIFN treatment significantly inhibited MSV-induced tumor growth.
    • Low-dose MuIFN treatment (either daily or intermittently) resulted in enhanced tumor growth.
    • The simultaneous administration of large doses of MuIFN and PDGF diminished the antitumor effect of MuIFN, suggesting an antagonistic interaction.

    Conclusions:

    • Mouse interferon (MuIFN) exhibits dose-dependent effects on Moloney sarcoma virus (MSV) tumor growth, with high doses being inhibitory and low doses being stimulatory.
    • Bovine platelet-derived growth factor (PDGF) interacts with MuIFN in vivo, modulating its effect on tumor growth.
    • A complex interplay exists between interferon and growth factors, influencing tumor development and suggesting potential therapeutic strategies.

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