Related Experiment Video
Updated: Aug 15, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
Large cell acanthoma. One of the actinic keratoses
Abstract:
Large cell acanthoma (LCA), which was first introduced to the dermatologic literature in 1970 and has had no major presentation since then, is not an uncommon lesion. The lesion is a circumscribed hyperkeratotic epidermal growth with the outstanding pathologic feature being large cells. Clinical diagnoses have included several benign and malignant skin conditions. Large cell acanthoma may be related to lichen planus-like keratosis and lentigo senilis. We diagnosed 38 instances of LCA among 34,000 specimens received in our dermatopathology laboratory.
Related Concept Videos
Abnormal Proliferation
Actin Polymerization and Cell Motility
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.
Clinical Applications of Epidermal Stem Cells
Cells of the Epidermis
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

