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Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

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Related Experiment Video

Updated: Jul 17, 2026

In Vivo Imaging of Transgenic Gene Expression in Individual Retinal Progenitors in Chimeric Zebrafish Embryos to Study Cell Nonautonomous Influences
10:36

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pp60c-src is developmentally regulated in the neural retina.

L K Sorge, B T Levy, P F Maness

    Cell
    |February 1, 1984
    PubMed
    Summary

    Normal cellular pp60c-src (a protein tyrosine kinase) is crucial for developing chick neural retina neurons. Its expression is vital for neuronal differentiation and function, not cell proliferation.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Developmental Biology

    Background:

    • The src gene product, pp60v-src, is a well-studied protein tyrosine kinase.
    • The role of the normal cellular counterpart, pp60c-src, in neural development is less understood.

    Purpose of the Study:

    • To investigate the localization and expression patterns of pp60c-src in the developing chick neural retina.
    • To determine the role of pp60c-src during neuronal differentiation and maturation.

    Main Methods:

    • Immunocytochemical staining using antisera against pp60v-src.
    • Protein kinase assays.
    • Western transfer analyses.

    Main Results:

    • pp60c-src was detected in developing retinal neurons at the onset of differentiation.

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  • Expression persisted in mature, postmitotic, and functional neuronal cells.
  • Immunoreactivity was observed in ganglion neurons, photoreceptor cells (rods and cones), and some inner nuclear layer neurons.

    • Conclusions:

    • pp60c-src is a product of a developmentally regulated gene in the neural retina.
    • pp60c-src plays a significant role in neuronal differentiation and function, rather than cell proliferation.