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Related Experiment Videos

Auditory and visual evoked potentials in Huntington's disease.

R C Josiassen, C Shagass, E L Mancall

    Electroencephalography and Clinical Neurophysiology
    |February 1, 1984
    PubMed
    Summary

    Huntington's disease (HD) patients show reduced auditory and visual evoked potential amplitudes. While peak latencies are similar, early auditory evoked potential (AEP) N100 is faster in HD, and medication may further lower amplitudes.

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    Area of Science:

    • Neuroscience
    • Clinical Neurology

    Background:

    • Huntington's disease (HD) is a progressive neurodegenerative disorder.
    • Evoked potentials (EPs) are valuable tools for assessing neural pathway integrity.

    Purpose of the Study:

    • To investigate auditory evoked potentials (AEPs) and visual evoked potentials (VEPs) in Huntington's disease patients.
    • To compare EP abnormalities in HD patients with healthy controls.

    Main Methods:

    • Recorded AEPs and VEPs from 15 locations in 21 HD patients and 21 matched controls.
    • Analyzed peak latencies and amplitudes of various EP components.

    Main Results:

    • No significant differences in most peak latencies, except for an earlier AEP N100 peak in HD patients.

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  • Reduced amplitudes for both VEP and AEP components in HD patients compared to controls.
  • VEP and AEP amplitudes were lower in medicated HD patients than unmedicated ones.

    • Conclusions:

    • HD is associated with non-specific reductions in VEP and AEP amplitudes.
    • Early EP components do not show specific abnormalities in HD.
    • Medication may exacerbate the reduction in EP amplitudes in HD patients.