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6-azauridine triacetate induced hyper beta-alaninemia and its decrease by administration of pyridoxine.

M Slavik, O Blanc, K J Smith

    Journal of Nutritional Science and Vitaminology
    |October 1, 1983
    PubMed
    Summary
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    Pyridoxine (vitamin B6) can reduce high beta-alanine levels caused by 6-azauridine triacetate (6-AzUrd-TA) in rabbits. This suggests 6-AzUrd-TA may inhibit enzymes that break down beta-alanine.

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Animal Studies

    Background:

    • 6-azauridine triacetate (6-AzUrd-TA) is a compound that can induce hyper beta-alaninemia.
    • Beta-alanine is an amino acid with various physiological roles.
    • Pyridoxine, also known as vitamin B6, is a crucial coenzyme in many metabolic processes.

    Purpose of the Study:

    • To investigate the effect of pyridoxine on 6-azauridine triacetate (6-AzUrd-TA) induced hyper beta-alaninemia in New Zealand albino rabbits.
    • To explore the potential role of pyridoxal phosphate-dependent enzymes in the mechanism of 6-AzUrd-TA induced hyper beta-alaninemia.

    Main Methods:

    • Three experiments were conducted using New Zealand albino rabbits.
    • Animals were divided into three groups: control (drinking water), 6-AzUrd-TA administration, and 6-AzUrd-TA with pyridoxine administration.

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  • Serum beta-alanine concentrations were measured on days 4 and 7 of treatment.

    • Main Results:

    • Oral administration of 6-AzUrd-TA (1.0 g/kg or 0.5 g/kg B.W.) led to significantly elevated serum beta-alanine levels.
    • Simultaneous administration of pyridoxine (50 mg/kg B.W.) significantly reduced the 6-AzUrd-TA induced hyper beta-alaninemia in all experiments (p <= 0.05).
    • No beta-alanine was detected in control animals or pre-treatment samples.

    Conclusions:

    • Repeated oral administration of 6-AzUrd-TA causes elevated serum beta-alanine levels in rabbits.
    • Pyridoxine administration partially prevents this elevation, suggesting a role for pyridoxal phosphate-dependent enzymes.
    • The findings indirectly support the hypothesis that 6-AzUrd-TA induced hyper beta-alaninemia is partly due to the inhibition of beta-alanine degrading enzymes.