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Acute oral poisoning with lindane-solvent mixtures
Veterinary and Human Toxicology
|February 1, 1984
Summary
Oral ingestion of lindane-solvent mixtures caused severe symptoms, including seizures, in six patients. Prompt medical intervention with diazepam and adsorbents led to complete recovery for all individuals.
Area of Science:
- Toxicology
- Environmental Health
Background:
- Lindane and benzene are common industrial solvents.
- Oral intoxication with lindane-solvent mixtures presents a significant public health concern.
Observation:
- Six cases of oral lindane-solvent mixture intoxication were reviewed.
- Patients ingested mean doses of lindane (120 mg/kg) and benzene (366 mg/kg), exceeding toxic levels.
- Symptoms included vomiting, dizziness, hyperreflexia, and epileptiform seizures within 30 minutes.
Findings:
- All six patients experienced epileptiform seizures.
- Two patients developed pulmonary edema, and one had severe rhabdomyolysis.
- Diazepam effectively controlled convulsions in five patients.
- Gastric lavage, activated charcoal, liquid paraffin, and cholestyramine were utilized as adsorbents.
Implications:
- Early recognition and management of lindane-solvent poisoning are crucial.
- Prompt administration of anticonvulsants and gastrointestinal decontamination can lead to favorable outcomes.
- This case series highlights the severe neurotoxicity and systemic effects of lindane-solvent mixtures.