[Changes in the monooxygenase activity of the mouse liver by the activity of high-molecular immunomodulators]

Activity of mice hepatocyte monooxygenases was studied in dynamics of immune response to administration of sheep erythrocytes and phytohemagglutinin. During the primary and secondary immune response the antigen inhibited activity of cytochrome P-450-dependent reactions (N-demethylase and p-hydroxylase), which was apparently due to synthesis of interferon. At the same time, activity of cytochrome P-448-dependent system (benz-alpha-pyrene hydroxylase) was 1.5-5-fold increased as compared with controls as a result apparently of its participation in synthesis of immunoregulators.