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Scleritis and associated disease.

S M Lachmann, B L Hazleman, P G Watson

    British Medical Journal
    |January 14, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Scleral disease, though uncommon, is linked to autoimmune connective-tissue disorders like rheumatoid arthritis. Early diagnosis and treatment are crucial due to potential severe complications and systemic risks.

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    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Immunology

    Background:

    • Scleral disease is an uncommon condition.
    • It is often associated with underlying connective-tissue disorders.
    • Scleritis can lead to severe local destruction and systemic complications.

    Purpose of the Study:

    • To investigate the prevalence of autoimmune markers in patients with scleral disease.
    • To explore the association between scleral disease and connective-tissue disorders.
    • To highlight the importance of early diagnosis and effective treatment for scleral disease.

    Main Methods:

    • Medical examination of 100 consecutive patients presenting with scleral disease.
    • Assessment for seropositive rheumatoid arthritis.
    • Rheumatoid factor testing (Rheumaton test).

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  • Analysis of autoantibody presence and its correlation with disease type and patient demographics.

    • Main Results:

    • 35% of patients with scleral disease had autoantibodies.
    • Rheumatoid factor was present in 13 patients with rheumatoid arthritis and an additional 16 patients.
    • Autoantibodies were most common in elderly patients and in cases of necrotising and diffuse scleritis.
    • Scleral disease is associated with connective-tissue disorders.

    Conclusions:

    • Scleral disease frequently presents with autoimmune markers, particularly rheumatoid factor.
    • The presence of autoantibodies is more common in specific types of scleritis and in older individuals.
    • Prompt diagnosis and management of scleral disease are vital due to its association with systemic conditions and potential for severe outcomes.