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Anti-infectious properties of the complex of bivalent copper with 3-mercapto-2-hydroxypropyl ether of dextran (C-79)
Abstract:
The anti-infectious activity of the C-79 preparation was examined on mice intravenously infected with Shigella sonnei dysentery of phase I. The activity of the preparation was determined taking into account the number of bacteria cultured from the organs of the examined animals and the number of animals surviving the infection as compared with the control. C-79 preparation administered to the mice before the infection was observed to protect then from death almost in 100%. The activity of the preparation differed according to the strategy of administration.
Insights
The C-79 preparation demonstrated significant anti-infectious activity against Shigella sonnei dysentery in mice. Administering C-79 before infection provided nearly 100% protection, with effectiveness varying by administration strategy.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Shigella sonnei causes bacillary dysentery, a significant public health concern.
- Developing effective anti-infective agents is crucial for combating bacterial infections.
Purpose of the Study:
- To evaluate the anti-infectious efficacy of the C-79 preparation against Shigella sonnei.
- To determine the protective effect of C-79 in a murine model of dysentery.
Main Methods:
- Mice were intravenously infected with Shigella sonnei (phase I).
- The C-79 preparation was administered to mice.
- Bacterial counts in organs and animal survival rates were assessed and compared to controls.
Main Results:
- C-79 administration prior to infection resulted in nearly 100% survival of mice.
- The anti-infectious activity was confirmed by reduced bacterial load in organs.
- Preparation efficacy varied depending on the administration strategy.
Conclusions:
- The C-79 preparation exhibits potent anti-infectious properties against Shigella sonnei.
- C-79 shows promise as a therapeutic agent for Shigella infections.
- Further research into optimal administration strategies for C-79 is warranted.