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Subcutaneous pseudosarcomatous polyvinylpyrrolidone granuloma.
The American Journal of Surgical Pathology
|May 1, 1984
Summary
Repeated injections of antihypertensive medication containing polyvinylpyrrolidone (PVP) can cause buttock induration. This cellular PVP granuloma may mimic sarcoma, highlighting the need for accurate pathological diagnosis.
Area of Science:
- Pathology
- Oncology
- Dermatology
Background:
- Polyvinylpyrrolidone (PVP) is a synthetic polymer used in various pharmaceutical preparations, including some antihypertensive remedies.
- Repeated administration of substances containing PVP can lead to localized tissue reactions.
Observation:
- A 77-year-old male presented with a buttock induration after repeated injections of an antihypertensive agent containing PVP.
- Surgical excision revealed a tumor with a cellular, pseudosarcomatous appearance and abundant extracellular material.
Findings:
- Histopathological examination and infra-red spectrophotometry confirmed the presence of PVP within the excised tissue.
- The lesion exhibited features that mimicked a myxoid liposarcoma.
Implications:
- This case underscores the importance of recognizing polyvinylpyrrolidone (PVP) granuloma as a potential mimic of soft tissue sarcoma.
- Awareness of this entity is crucial for surgical pathologists to prevent misdiagnosis and ensure appropriate patient management.