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Production of human interferons: an overview.
Developments in Biological Standardization
|January 1, 1983
Summary
Increased demand for human interferons (IFNs) drives diverse production methods. Various IFNs are now manufactured in large quantities for clinical trials, meeting strict health regulations.
Area of Science:
- Biotechnology
- Immunology
- Pharmaceutical Manufacturing
Background:
- Global demand for human interferons (IFNs) has surged, primarily for clinical trial applications.
- This increased demand necessitates robust and scalable production methodologies for various IFN types.
Purpose of the Study:
- To outline the diverse production procedures for different human interferons (IFNs).
- To highlight the methodologies employed for large-scale manufacturing of IFNs for clinical use.
Main Methods:
- Production of leukocyte, fibroblast, lymphoblastoid, immune, and recombinant IFNs.
- Utilizing specific producer cells, IFN inducers, and purification techniques.
- Employing various equipment for crude IFN production, concentration, and purification.
Main Results:
- Human IFNs are produced in large quantities using tailored methodologies.
- IFN preparations exhibit varying specific activities.
- Final products undergo rigorous testing to comply with health authority regulations.
Conclusions:
- Established procedures enable large-scale production of diverse human interferons.
- Methodologies are adapted to specific IFN types and producer cell characteristics.
- Strict quality control ensures the safety and efficacy of final IFN preparations for clinical use.