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Response of an abnormal sinus node to intravenous flecainide acetate
Pacing and Clinical Electrophysiology : PACE
|May 1, 1984
Summary
Flecainide, a class IC antiarrhythmic, significantly prolonged sinus node recovery and sinoatrial conduction times in a patient with sinus node disease. This effect was notable due to a concurrent subsidiary junctional pacemaker.
Area of Science:
- Electrophysiology
- Pharmacology
Background:
- Sinus node disease (SND) affects cardiac rhythm regulation.
- Vaughan Williams class IC antiarrhythmic agents are used for arrhythmias.
Observation:
- A patient with SND underwent provocative testing with flecainide.
- Flecainide is a novel Vaughan Williams class IC antiarrhythmic drug.
Findings:
- Provocative testing revealed dramatic increases in sinus node recovery times (SNRT).
- Sinoatrial conduction times (SACT) were significantly prolonged.
- A subsidiary junctional pacemaker emerged without retrograde atrial conduction, allowing observation of flecainide's effects.
Implications:
- Flecainide can significantly impact sinus node function.
- Understanding flecainide's effects is crucial for managing arrhythmias in patients with SND.
- The emergence of a subsidiary pacemaker highlights complex electrophysiological responses to flecainide.