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Total plasma kininogen in psoriasis and atopic dermatitis
Acta Dermato-Venereologica
|January 1, 1984
Summary
Total plasma kininogen levels are elevated in patients with extensive chronic inflammatory skin diseases like atopic dermatitis and psoriasis. Some atopic patients showed increased kininogen after calcium gluconate treatment.
Area of Science:
- Biochemistry
- Dermatology
- Immunology
Background:
- Plasma kininogen is a precursor to bradykinin, a vasoactive peptide involved in inflammation.
- The role of kininogen in chronic inflammatory skin conditions is not fully understood.
Observation:
- Total plasma kininogen levels were measured in 75 healthy individuals and patients with extensive dermatoses.
- Elevated kininogen levels were found in 20/30 hospitalized patients with atopic dermatitis.
- Elevated kininogen levels were also observed in 33 psoriasis patients.
Findings:
- Extensive chronic inflammatory skin disease correlates with elevated total plasma kininogen.
- Nine atopic patients exhibited increased plasma kininogen levels following intravenous calcium gluconate administration.
- Control injections and healthy individuals did not show similar kininogen level responses.
Implications:
- Elevated plasma kininogen may serve as a biomarker for severe inflammatory skin conditions.
- Calcium gluconate's effect on kininogen warrants further investigation in atopic dermatitis.
- Understanding kininogen's role could lead to novel therapeutic targets for dermatoses.
