Allotypic determinants (Igh-3) associated with the IgG2c subclass of rat immunoglobulins

Rat antibodies to group A streptococcal carbohydrate are primarily of the IgM and IgG isotypes. Hyperimmunization often results in antibodies of a restricted molecular heterogeneity of the IgG2c isotype. An allotypic marker, designated Igh-3a, was detected on the heavy chains of the IgG2c isotype from Copenhagen rats. Igh-3b was detected on the heavy chains of IgG2c from SHR rats. A strain distribution of the Igh-3 determinants as well as inheritance patterns for their expression are presented.