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Updated: Jul 20, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
13:45

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

Recognition of leukotriene B4 by a unique subset of human T-lymphocytes

D G Payan, E J Goetzl

    The Journal of Allergy and Clinical Immunology
    |September 1, 1984
    PubMed

    Leukotriene (LT) B4, but not 12(S)-LTB4 or LTC4, inhibits the generation of lymphokine-designated leukocyte inhibitory factor by purified human T-lymphocytes. LTB4 coupled to fluorescein-labeled human serum albumin interacts specifically with approximately 11% of the T-lymphocytes as assessed by fluorescence-activated flow cytometry. The LTB4-reactive T-lymphocytes are distributed between the suppressor-cytotoxic (14%) and helper-inducer (8%) subsets, which were identified concurrently by phycoerythrin-labeled monoclonal antibodies to subset-specific antigens. LTB4, but not 12(S)-LTB4 or LTC4, significantly enhances the proliferation of mitogen-stimulated purified suppressor-cytotoxic T-lymphocytes at concentrations of 10(-12)M to 10(-6)M and significantly inhibits the proliferation of mitogen-stimulated purified helper-inducer T-lymphocytes at concentrations of 10(-8)M to 10(-6)M, as assessed by the uptake of [3H]thymidine. The net effect of LTB4 on blood T-lymphocytes is immunosuppression that may be expressed in some human hypersensitivity and inflammatory diseases.

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