[1st experiences with the alpha-receptor blockader phentolamine in achalasia]

Through direct research on isolated human esophagus muscle systems in achalasia patients we found a deviation in the distribution pattern of the contractory alpha-receptors and dilatory beta-receptors in the region of the lower esophagus sphincter in favour of the alpha-receptors. Consequently, the motility of the lower esophagus sphincter was extremely impaired. On the basis of these results, we treated achalasia patients with the alpha receptor blocking drug phentolamine. All patients were soon symptom-free subjectively and improved objectively. Surgical intervention was avoidable in all cases.