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Updated: Aug 16, 2026

Gramicidin-based Fluorescence Assay; for Determining Small Molecules Potential for Modifying Lipid Bilayer Properties
Published on: October 13, 2010
[Interaction of salts of transition metals with gramicidin S in chloroform]
Abstract:
Extraction of CuCl2, NiCl2, CoCl2 and MnCl2 from the aqueous phase to the organic gramicidin S containing phase (the phase ratio of 1:1) was studied with the method of molar ratios at constant concentrations of the salts and changing concentrations of the antibiotic. The composition of the forming intracomplex compounds was determined with the equilibrium shift method. It was shown that 2 ions of chlorine and 2 molecules of gramicidin S bound with 1 ion of the metals. The extraction constants were measured. The complex compounds of gramicidin S with copper chloride were the most stable.
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