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Inhibition by drugs of passive cutaneous anaphylaxis-induced skin histamine decrease.

H Yokoyama, K Shimamura, K Saeki

    Acta Medica Okayama
    |August 1, 1984
    PubMed
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    Salbutamol and aminophylline effectively reduced histamine release in rats during passive cutaneous anaphylaxis (PCA). Measuring skin histamine decrease is a reliable method to assess antiallergic drug efficacy in vivo.

    Area of Science:

    • Pharmacology
    • Immunology
    • Allergy Research

    Background:

    • Passive cutaneous anaphylaxis (PCA) is a model for allergic reactions.
    • Histamine release plays a key role in PCA.
    • Assessing antiallergic drug efficacy in vivo is crucial.

    Purpose of the Study:

    • To evaluate the effects of salbutamol, cromoglycate, and aminophylline on PCA in rats.
    • To determine if skin histamine decrease can serve as an in vivo marker for antiallergic drug activity.

    Main Methods:

    • PCA was induced in rats using mouse IgE-rich antiserum.
    • The impact of drugs on skin histamine levels and protein-bound dye leakage was measured.
    • Salbutamol, cromoglycate, and aminophylline were administered intravenously (i.v.) or subcutaneously (s.c.).

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    Main Results:

    • Salbutamol and cromoglycate significantly inhibited PCA-induced skin histamine decrease.
    • Combined salbutamol and aminophylline showed additive or synergistic effects on histamine decrease.
    • Salbutamol markedly reduced dye leakage, while aminophylline had a slight effect.

    Conclusions:

    • Skin histamine decrease is a valid indicator for evaluating the in vivo inhibitory effects of antiallergic drugs.
    • Salbutamol and aminophylline demonstrate significant potential in mitigating allergic responses.
    • The study provides insights into the mechanisms of antiallergic drug action.