Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The human thymic microenvironment.

B F Haynes

    Advances in Immunology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This study identifies distinct regions within the human thymus microenvironment using monoclonal reagents. These findings offer insights into thymic epithelial cell differentiation and potential extrathymic T cell development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells.

    Mucosal immunology·2015
    Same author

    Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women.

    Mucosal immunology·2014
    Same author

    HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life.

    Mucosal immunology·2013
    Same author

    Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants.

    Journal of virology·2009
    Same author

    Leukocyte homing to synovium.

    Current directions in autoimmunity·2002
    Same author

    Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy.

    AIDS research and human retroviruses·2002
    Same journal

    The roles and diversity of alarmins in the mucosae.

    Advances in immunology·2026
    Same journal

    Principles of resident tissue macrophages revealed by the eye.

    Advances in immunology·2026
    Same journal

    Beyond suppression: Treg specialization in infection and tissue repair.

    Advances in immunology·2026
    Same journal

    Ontogeny and function of microglia and nerve-associated macrophages.

    Advances in immunology·2025
    Same journal

    Neuroimmunology beyond the CNS: Nerve-macrophage interactions in peripheral tissues.

    Advances in immunology·2025
    Same journal

    Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination.

    Advances in immunology·2025
    See all related articles

    Area of Science:

    • Immunology
    • Developmental Biology
    • Cell Biology

    Background:

    • The human thymus microenvironment is crucial for T lymphocyte maturation.
    • Understanding the cellular composition and differentiation pathways of the thymus is essential for immunology research.

    Purpose of the Study:

    • To phenotypically identify and characterize major regions of the human thymus microenvironment.
    • To investigate potential markers for thymic epithelial cells and their role in T cell development.
    • To explore the concept of thymic epithelial differentiation and its developmental phases.

    Main Methods:

    • Utilized monoclonal reagents for phenotypic identification of thymic microenvironment regions.
    • Analyzed antigen expression patterns on thymic epithelial cells and keratinocytes.

    Related Experiment Videos

  • Reviewed literature to define developmental phases of the thymic microenvironment.

    • Main Results:

    • Identified four major regions: thymic capsule/stroma (TE-7+), subcapsular cortex (TE-4+, Thy-1+, A2B5+, anti-p19+, BB TECS+, TE-3+), cortex (TE-3+), and medulla (TE-4+, A2B5+, anti-p19+, BB TECS+).
    • TE-4+ and TE-3+ thymic epithelium subsets are candidates for conferring MHC restriction to T lymphocytes.
    • Identified potential thymic epithelial lineage markers (TE-4, anti-p19, BB TECS) that may also be present in extrathymic T cell differentiation sites.
    • Evidence suggests continuous differentiation of thymic epithelium, potentially involving a maturation pathway similar to skin keratinocytes.
    • Defined three phases of thymic microenvironment development, from initial mesenchymal induction to thymocyte precursor colonization.

    Conclusions:

    • Monoclonal reagents enable detailed phenotyping of the human thymus microenvironment.
    • Specific thymic epithelial subsets play roles in T cell development and MHC restriction.
    • Thymic epithelial markers may indicate extrathymic T cell differentiation.
    • Thymic epithelium undergoes continuous differentiation, with potential parallels to keratinocyte maturation.
    • The developmental stages of the thymus involve intricate interactions between mesenchymal stroma and thymic epithelium.