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Accidental dapsone poisoning in children.

P M Nair, E Philip

Annals of Tropical Paediatrics

|December 1, 1984

Summary

Accidental childhood poisoning is rising, with dapsone emerging as a significant concern. Prompt treatment with intravenous ascorbic acid and supportive care effectively managed dapsone-induced methaemoglobinaemia in children.

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Area of Science:

Pediatrics
Toxicology
Public Health

Background:

Childhood accidental poisoning is an increasing public health issue, often involving household drugs and chemicals.
A notable trend indicates a rise in poisonings due to newer pharmaceutical agents.
Safe storage of medications is crucial to prevent pediatric exposure.

Purpose of the Study:

To analyze the trends and causes of accidental poisoning in children admitted to Sree Avittam Thirunal Hospital (SATH).
To specifically investigate the incidence and management of dapsone poisoning in pediatric cases.
To highlight the importance of medication safety in households with young children.

Main Methods:

Retrospective analysis of pediatric admissions at SATH, Trivandrum, during 1982.
Identification and categorization of all cases of accidental poisoning.
Detailed review of dapsone poisoning cases, including clinical presentation and treatment outcomes.

Main Results:

Sixty-one cases of accidental poisoning were recorded, representing 0.61% of total pediatric admissions.
Dapsone poisoning accounted for 9.8% of all accidental poisoning cases.
Dapsone poisoning led to methaemoglobinaemia, which responded favorably to intravenous ascorbic acid and supportive care.

Conclusions:

Dapsone poisoning is a significant cause of accidental poisoning in children, necessitating improved drug storage practices.
Intravenous ascorbic acid is an effective treatment for dapsone-induced methaemoglobinaemia in pediatric patients.
Public health awareness regarding safe medication storage is vital to reduce childhood poisoning incidents.

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