Hexokinase isoenzymes: antigenic cross-reactivities and amino acid compositional relatedness

Previously undetected antigenic cross-reactivities have been demonstrated between yeast and rat hexokinase isoenzymes using an enzyme-linked immune sorbent assay. The levels of structural homology between the isoenzymes have been assessed in terms of their relative antigenic cross-reactivities and their amino acid compositional relatedness. The three major rat hexokinases appear, despite their differing molecular sizes, to have a close evolutionary background and to share a common but distant ancestry with yeast and wheat-germ forms.