Penetrating duodenal ulcer associated with an operatively implanted arterial chemotherapy infusion catheter

A 65-yr-old man with hepatic metastases from adenocarcinoma of the colon treated with hepatic arterial infusion of 5-fluoro-2'-deoxyuridine and radiation therapy, presented with major gastrointestinal bleeding from an endoscopically documented giant duodenal ulcer with a portion of the hepatic arterial catheter visible in the ulcer crater. A penetrating giant duodenal ulcer was confirmed during an operative procedure. This patient with giant duodenal ulcer penetration associated with an operatively implanted arterial infusion catheter represents an unusual complication of this form of chemotherapy for hepatic tumors.