Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skeletal muscle calcergy.

J McClure

    The Journal of Pathology
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Diphosphonates EHDP and Cl2MDP did not prevent muscle fiber calcification in mouse models. This suggests these compounds are unlikely to be effective treatments for myopathies involving calcium influx.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Image reconstruction and analysis of atherosclerosis imaging by [<sup>18</sup>F]FDG PETCT using digital PET technology.

    European journal of nuclear medicine and molecular imaging·2025
    Same author

    Observational study on antimicrobial resistance in <i>Escherichia coli</i> and <i>Salmonella</i> isolates from Ontario calf samples submitted to a diagnostic laboratory from 2007 to 2020.

    The Canadian veterinary journal = La revue veterinaire canadienne·2022
    Same author

    Dairy producer satisfaction and knowledge transfer with the veterinary-administered risk assessment and management plan in a voluntary Johne's disease control program.

    Journal of dairy science·2022
    Same author

    Associations between colostrum management, passive immunity, calf-related hygiene practices, and rates of mortality in preweaning dairy calves.

    Journal of dairy science·2019
    Same author

    Demographic Factors Associated with Prince Edward Island Horse Farm Owner Awareness of the <i>Code of Practice for the Care and Handling of Equines</i>.

    Journal of applied animal welfare science : JAAWS·2019
    Same author

    An observational study on passive immunity in Irish suckler beef and dairy calves: Tests for failure of passive transfer of immunity and associations with health and performance.

    Preventive veterinary medicine·2018

    Area of Science:

    • Muscle physiology
    • Pathology
    • Pharmacology

    Background:

    • Subcutaneous injection of mast cell degranulators or KMnO4 in mice induces calcification of Panniculus Carnosus muscle fibers.
    • This calcification occurs in damaged fibers near necrosis or uniformly at the reaction site, respectively.
    • Calcium influx into muscle fibers is a proposed mechanism in various myopathies.

    Purpose of the Study:

    • To investigate the effect of diphosphonates (EHDP and Cl2MDP) on chemically induced muscle fiber calcification in mice.
    • To evaluate the potential of diphosphonates as a therapeutic strategy for myopathies characterized by calcium influx.

    Main Methods:

    • Subcutaneous injections of mast cell degranulators and KMnO4 were administered to mice.
    • Muscle tissue was analyzed qualitatively and quantitatively following injections.

    Related Experiment Videos

  • The influence of EHDP and Cl2MDP treatments on calcific responses was assessed.

    • Main Results:

    • Neither EHDP nor Cl2MDP treatments affected the calcification of muscle fibers induced by either agent.
    • The study observed distinct patterns of calcification depending on the inducing chemical (mast cell degranulators vs. KMnO4).

    Conclusions:

    • The tested diphosphonates are unlikely to be efficacious in preventing muscle fiber calcification.
    • The findings suggest that diphosphonates may not be suitable for treating myopathies where muscle fiber calcification is driven by calcium influx.