[Effect of acute administration of verapamil on various metabolic parameters in healthy humans]

Calcium-antagonist drugs have been used for sometime in various forms of cardiac disease. Some of these molecules, in the initial phase of administration, show a net increase in the FFA liberation. So far it is not certain whether this behavior also refers to other molecules. Therefore we studied the action of verapamil on FFA, on glycemia and on insulinemia. The drug was administered orally (single dose of 80 mg) and intravenously (single dose of 10 mg in 45 m'). 15 healthy subjects were examined, 7 women and 8 men, aged from 19 to 45. These subjects were also used as controls, administered with placebo. Our findings show that this calcium-antagonist drug is not capable of interfering with the studied metabolic parameters.