Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium ratio and maintenance treatment response.

J H Kocsis, J S Kantor, K W Lieberman

    Journal of Affective Disorders
    |September 1, 1982
    PubMed
    Summary

    The erythrocyte/plasma lithium ratio does not reliably predict treatment response in bipolar disorder patients. This study found no significant correlation between lithium ratios and patient outcomes during long-term maintenance therapy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder.

    Acta psychiatrica Scandinavica·2015
    Same author

    ABCB1 (MDR1) predicts remission on P-gp substrates in chronic depression.

    The pharmacogenomics journal·2014
    Same author

    Hypercortisolemia decreases dexamethasone half-life in rabbit.

    Journal of psychiatric research·2002
    Same author

    New psychopharmacologic treatment strategies.

    Annals of internal medicine·2001
    Same author

    Lithium isotopes: differential effects on renal function and histology.

    Bipolar disorders·2001
    Same author

    Sertraline versus imipramine to prevent relapse in chronic depression.

    Journal of affective disorders·2001

    Area of Science:

    • Psychiatry
    • Pharmacology
    • Clinical Chemistry

    Background:

    • Lithium is a cornerstone treatment for bipolar disorder.
    • Predicting individual patient response to lithium remains a clinical challenge.
    • The erythrocyte/plasma lithium ratio has been investigated as a potential biomarker for lithium efficacy.

    Purpose of the Study:

    • To investigate the correlation between the erythrocyte/plasma lithium ratio and clinical response in bipolar disorder outpatients.
    • To determine if lithium ratio can differentiate between lithium responders and non-responders.
    • To assess the utility of erythrocyte/plasma lithium ratio in long-term lithium maintenance therapy.

    Main Methods:

    • Erythrocyte and plasma lithium levels were measured in 41 bipolar outpatients on long-term lithium treatment.
    • Patients were categorized based on their history of affective episodes during maintenance therapy.
    • Lithium ratios were compared between groups identified as lithium non-responders and apparent responders.

    Main Results:

    • A group of 16 patients identified as lithium non-responders had a mean erythrocyte/plasma lithium ratio of 0.50.
    • Eighteen patients with no affective episodes (apparent responders) had a mean ratio of 0.52.
    • The difference in mean lithium ratios between non-responders and apparent responders was not statistically significant.

    Conclusions:

    • The erythrocyte/plasma lithium ratio does not appear to correlate with the clinical response of bipolar outpatients to maintenance lithium therapy.
    • Current findings suggest that lithium ratio is not a reliable predictor of lithium efficacy in this patient population.
    • Further research may be needed to identify reliable biomarkers for lithium response in bipolar disorder.

    Related Experiment Videos