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Piperacillin in paediatric surgery.

J Gierup, T Linglöf, O Cars

    Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery in Infancy and Childhood
    |June 1, 1982
    PubMed
    Summary
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    Piperacillin, a broad-spectrum penicillin antibiotic, demonstrated effectiveness and safety in treating various infections in 23 infants and children. Clinical responses were positive with minimal adverse reactions observed during the study.

    Area of Science:

    • Pediatric Infectious Diseases
    • Pharmacology
    • Antimicrobial Agents

    Background:

    • Piperacillin is a novel semi-synthetic penicillin.
    • It exhibits broad-spectrum antimicrobial activity.
    • Its use in pediatric populations requires evaluation.

    Purpose of the Study:

    • To assess the efficacy and safety of piperacillin in pediatric patients.
    • To evaluate piperacillin's effectiveness across diverse infection types.
    • To document adverse reactions associated with piperacillin treatment in children.

    Main Methods:

    • A cohort of 23 infants and children (aged 1 month to 15 years) received piperacillin.
    • Indications included perforated appendicitis, urinary tract infections, miscellaneous infections, and prophylactic treatment.

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  • Clinical outcomes and adverse events were monitored.

    • Main Results:

    • Good clinical responses were observed in the treated patients.
    • Piperacillin was effective in managing perforated appendicitis with peritonitis or abscess.
    • Few adverse reactions were reported, indicating a favorable safety profile.

    Conclusions:

    • Piperacillin appears to be an effective and safe treatment option for various infections in pediatric patients.
    • The antibiotic demonstrated a good clinical response with a low incidence of adverse effects.
    • Further investigation into piperacillin's role in pediatric infectious disease management is warranted.