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Antibody-specific immunoregulation is restricted by the major histocompatibility gene complex
Experiments were carried out to examine the major histocompatibility complex (MHC) restriction of an antibody-specific immunoregulatory function that develops following conventional immunization with hapten-carrier conjugates. It was found that carrier-primed hosts reconstituted with Ly-2.2+ T cells from hapten-carrier-immunized donors were able to suppress adoptively transferred primary B cells. The effective suppression of primary B cell responses was dependent on syngeny between the suppressing T cell population and the target B cells at both MHC and Igh. These findings indicate that T cells that function through the recognition of B cell antibody are restricted in their function by gene products of the MHC, similar to the restrictions observed for the recognition of conventional antigens.
Experiments were carried out to examine the major histocompatibility complex (MHC) restriction of an antibody-specific immunoregulatory function that develops following conventional immunization with hapten-carrier conjugates. It was found that carrier-primed hosts reconstituted with Ly-2.2+ T cells from hapten-carrier-immunized donors were able to suppress adoptively transferred primary B cells. The effective suppression of primary B cell responses was dependent on syngeny between the suppressing T cell population and the target B cells at both MHC and Igh. These findings indicate that T cells that function through the recognition of B cell antibody are restricted in their function by gene products of the MHC, similar to the restrictions observed for the recognition of conventional antigens.