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Contact dermatitis caused by diphenhydramine hydrochloride
Journal of the American Academy of Dermatology
|February 1, 1983
Summary
Diphenhydramine hydrochloride (Benadryl) can cause allergic contact dermatitis. Patients experiencing this reaction should avoid related ethanolamine antihistamines due to potential cross-reactivity, preventing further skin reactions.
Area of Science:
- Dermatology
- Allergology
- Pharmacology
Background:
- Contact dermatitis is a common skin reaction.
- Antihistamines are widely used for allergic conditions.
Observation:
- Three cases of contact dermatitis linked to diphenhydramine hydrochloride (Benadryl) are presented.
- Patients exhibited localized or generalized dermatitis flares upon exposure.
Findings:
- Diphenhydramine hydrochloride, an ethanolamine antihistamine, can trigger allergic contact dermatitis.
- Other ethanolamine antihistamines like dimenhydrinate, clemastine fumarate, carbinoxamine maleate, and doxylamine succinate may cause cross-react reactions.
Implications:
- Individuals with diphenhydramine-induced contact dermatitis should avoid oral or parenteral administration.
- Caution is advised when prescribing related ethanolamine antihistamines to sensitive patients to prevent adverse reactions.