Related Experiment Videos
The active T rosette: an early marker for T-cell activation.
Annales D'Immunologie
|September 1, 1982
Summary
The active T-rosette assay identifies a T lymphocyte subpopulation that recognizes antigens and modulates B-cell production. This assay serves as an early marker for lymphocyte activation, correlating with other immune response tests.
Area of Science:
- Immunology
- Cellular Immunology
Background:
- The active T-rosette assay identifies a specific T lymphocyte subpopulation.
- These T lymphocytes possess high-avidity receptors for sheep red blood cells and are Ia-positive.
Purpose of the Study:
- To review recent observations on the active T-rosette assay.
- To highlight its role as an early marker for lymphocyte activation.
Main Methods:
- The active T-rosette assay identifies T lymphocytes with high-avidity receptors.
- Assay performance under suboptimal conditions was observed.
- Correlation with lymphocyte stimulation tests and mixed lymphocyte cultures was assessed.
Main Results:
- Active T-rosette populations recognize and kill allogeneic cells and modulate B-cell immunoglobulin production.
- In vivo correlation with cutaneous reactivity and in vitro increase after antigen incubation were observed.
- The assay correlates with lymphocyte stimulation tests and identifies HLA D-DR region involvement in mixed lymphocyte cultures.
Conclusions:
- The neoformation of active T rosettes is linked to a rosetting factor release.
- Modulating drugs increase active T rosette percentages.
- Active T rosettes are an early marker for lymphocyte activation.