[Ultrastructural study of acute ischemia at the peripheral level. Effects of 5023 SE]

The effects of ischaemia on the arterial wall were studied in fragments of common carotid artery taken downstream from the occlusion. They consisted of intracytoplasmic or intrajunctional lacunae, vacuoles, craters, detachment or disruption of cell membranes with formation of blebs or bullae, retraction of numerous nuclei, swelling of the ergastoplasm and perhaps increase in pinocytosis. The administration of Duxil, a corrector of metabolism, 10 min prior to inducing ischaemia resulted in considerable reduction of these lesions as compared to untreated animals.