[Ultrastructure of "acrobullous dermatosis" induced by PUVA-therapy in psoriasis]

Report about a 44-year-old psoriatic female who developed recurrent bullous eruptions on her extremities during oral photochemotherapy. Ultrastructural analysis revealed an epidermolytic blister formation due to cytolytic alteration of infranuclear parts of basal cells. Pathogenetically, an initial subclinical phototoxic alteration of the epidermodermal coherence is assumed which may lead to a visible bulla by an additional mechanical trauma. There was no evidence for a subclinical bullous pemphigoid.