Influence of cider on the fibrinolytic enzyme system

Ingestion of 750 ml cider inhibited plasma fibrinolytic activity: unfermented apple juice appeared to have some inhibitory effect, but this did not reach statistical significance. Cider inhibited urokinase-induced clot lysis in a concentration-dependent manner; the inhibitory activity was heat-stable and non-dialysable. The fibrinolytic activities of plasmin, urokinase and, more markedly, tissue activator on fibrin plates were inhibited by cider in a concentration-dependent manner. The amidolytic activity of plasmin was also inhibited in the presence of cider.