[Monotherapy with clobazam in epilepsies in children]

Twenty-five epileptic children were treated with clobazam alone for periods of 10 days to 36 months (mean = 9 months and 16 months for children who responded well). Satisfactory results were obtained in 11 patients and marked improvement with a 75% decrease in the initial frequency of seizures in 6 patients. The seizures recurred after a few weeks in 3 other patients. This preliminary study shows that clobazam is well tolerated and remarkably effective, especially in benign partial epilepsy, even in carbamazepine-resistant cases.