Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Molecular abnormalities in recurrent thromboembolic disease].

E Dupuy, G Tobelem, C Soria

    Presse Medicale (Paris, France : 1983)
    |January 15, 1983
    PubMed
    Summary

    Recurrent thromboembolic disease (RTED) is often linked to inherited coagulation and fibrinolysis factor abnormalities. Identifying these genetic factors is crucial for diagnosing and managing familial RTED.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cognitive Functioning in Adults with Phenylketonuria in a Cohort of Spanish Patients.

    Behavioural neurology·2023
    Same author

    Definition of minimal disease activity in psoriasis.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same author

    [Prevalence of osteoarticular infections by Enterobacteria producing extended-spectrum -lactamases].

    Acta ortopedica mexicana·2020
    Same author

    A quantitative and semi-automatic measurement of transverse sinus stenosis improves idiopathic intracranial hypertension diagnostic accuracy.

    Journal of neuroradiology = Journal de neuroradiologie·2018
    Same author

    Redefining the therapeutic objective in psoriatic patients candidates for biological therapy.

    The Journal of dermatological treatment·2017
    Same author

    Strain-Gradient Position Mapping of Semiconductor Quantum Dots.

    Physical review letters·2017

    Area of Science:

    • Hematology
    • Genetics
    • Vascular Biology

    Context:

    • Recurrent thromboembolic disease (RTED) presents diagnostic and therapeutic challenges.
    • Recent research highlights the significance of coagulation and fibrinolysis factor abnormalities in RTED.
    • Familial RTED cases are increasingly linked to specific genetic defects.

    Purpose:

    • To investigate the role of inherited coagulation and fibrinolysis disorders in recurrent thromboembolic disease.
    • To identify specific genetic abnormalities associated with severe familial RTED.
    • To elucidate the mechanisms by which dysfibrinogenemia and plasminogen defects contribute to RTED.

    Summary:

    • Hereditary antithrombin III (AT III) deficiency/abnormalities and protein C deficiency are associated with severe familial RTED.

    Related Experiment Videos

  • A described dysfibrinogenemia impacts fibrin polymerization and plasminogen binding, causing familial RTED.
  • Reduced vascular plasminogen activator release/production by endothelial cells is observed in 70% of RTED cases.
  • Rare hereditary plasminogen deficiency or abnormalities are consistently linked to RTED.

    • Impact:

    • Improved understanding of the genetic underpinnings of RTED.
    • Potential for enhanced diagnostic strategies for familial thromboembolic events.
    • Foundation for developing targeted therapies for inherited thrombotic disorders.